abrogate – Communicable Diseases Research

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 치료제,

Identification of genomic determinants contributing to cytokine release in immunotherapies and human diseases

면역 요법 및 인간 질병에서 사이토카인 방출에 기여하는 게놈 결정인자의 식별

Article

Published on 2022-07-282022-09-11
Journal: Journal of Translational Medicine
[Category] Coronavirus, 유전자 메커니즘,

[키워드] abrogate Analysis Autoimmune diseases CAR CAR T-cell therapy CD22 cells cellular Cohort cohorts collected contribute contributing to CRS cytokine release Cytokine release syndrome dataset determinant develop driving drugs targeting expression Frequency genomic Glycolysis human disease identification immune system Immunotherapy IMPROVE in vivo Infection Influenza influenza infection influenza infections lupus erythematosus management mRNA not increased occur outcomes pathway Patient patients with influenza PFKFB4 PFKFB4. platform Prevent reaction reduce RNA extraction severity SLE syndrome systemic lupus erythematosus T-cell T-cells targeted therapy therapy tissues Treatment Tumor upregulated was used were used while with COVID-19
[DOI] 10.1186/s12967-022-03531-3 PMC 바로가기 [Article Type] Article

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

억제되지 않은 HIV 감염은 SARS-CoV-2 감염에 대한 T 세포 반응을 손상시키고 T 세포 교차 인식을 폐지합니다

Article

Published on 2022-07-262022-09-11
Journal: eLife
[Category] COVID19(2023년), SARS, 변종,

[키워드] abrogate abrogation Beta Beta variant CD4 CD8 correlated COVID-19 disease COVID-19 epidemic Cytometry determine diminishe epitope epitope specificity explain First wave Flow flow cytometry greater highlight HIV HIV infection Human identify immunodominance immunology impair in some individual Infection Inflammation Inflammation. instances mechanism mononuclear cell Mutation peptide peptide pools Peripheral blood PLWH Protein Recognition SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants second wave severe COVID-19 severe COVID-19 disease significantly South Africa specificity Spike protein susceptibility T cell T cell activation T cell response T cell responses the Spike variant was used with HIV
[DOI] 10.7554/eLife.78374 PMC 바로가기 [Article Type] Article

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4 + T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19

장기간의 COVID-19가 있는 항-CD20 치료를 받은 환자에서 높고 지속되는 생체외 빈도이지만 SARS-CoV-2-특이적 CD4 + T-세포의 변경된 표현형

Article

Published on 2022-06-102022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 치료기술,

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

SARS-CoV-2 Nsp13은 NKG2A 발현 NK 세포의 억제를 폐지하는 HLA-E 안정화 펩티드를 암호화합니다

Article

Published on 2022-03-082022-09-11
Journal: Cell Reports
[Category] COVID19(2023년), SARS, 치료기술, 치료제,

[키워드] abrogate activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen binding Cell contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense detect ENCODE epithelial cells HLA-E Host host defense human leukocyte antigen immune cells in vitro infected cells infections inhibitory receptor innate immune cell Innate immune cells leukocyte limit lung epithelial cell mechanism missing self. natural NK cell NK cells NKG2A non-structural protein Patient patients with COVID-19 peptide Prevent Protein respond resulting SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cell SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus susceptible target cell target cells These data virus
[DOI] 10.1016/j.celrep.2022.110503 PMC 바로가기 [Article Type] Article

An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages

조작된 나노 리포솜 인간 ACE2 미끼는 쥐와 인간 대식세포 모두에서 SARS-CoV-2 스파이크 단백질 유도 염증을 중화합니다

Article

Published on 2022-03-062022-09-11
Journal: Theranostics
[Category] SARS, 유전자 메커니즘,

[키워드] abrogate abrogated ACE2 activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding biotinylated canonical CCL-2 chemokines competitive inhibitor complex coronavirus CXCL-10 cytokine D614G deficiency DEGs demonstrated differentially expressed gene Effect enzyme expressing expression fusion generate glycoprotein hACE2 human ACE2 human host cells human macrophage human macrophages IKKβ IKKβ/NF-κB signaling IL-1β IL-6 Immune cell immune cells in vitro in vivo Infection Inflammation Inflammatory response Inflammatory responses inhibit SARS-CoV-2 inhibitor internalization Intravenous injection IκB lentivirus Liposome Liposome-Human ACE2 Macrophage macrophages mechanism mice molecular murine myeloid-specific IKKβ knockout. neutralize NF-κB NF-κB activation NF-κB signaling Protein rationale receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 spike glycoprotein severe acute respiratory syndrome Coronavirus Signaling spike spike glycoprotein Spike protein stimulated Therapeutic approach tissue inflammation TNFα Treatment was used wild type
[DOI] 10.7150/thno.66831 PMC 바로가기 [Article Type] Article

Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating

Biochemistry

Published on 2021-12-202022-10-28
Journal: PeerJ
[Category] COVID-19,

A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling

Commentary

Published on 2021-11-102022-10-29
Journal: Purinergic Signalling
[Category] COVID-19, MERS,

[키워드] abrogate accompanied activate Activation adverse effect adverse effects anti-inflammatory activity Anti-inflammatory drugs ATP cell death cellular Co-infection COVID-19 COVID-19 patient criteria Critical Critically ill Cytokine storm develop drug expected extracellular ATP half-maximal effective concentration hyperinflammation immune Immune cell immune cells immune function Immune paralysis immune response Increased Inflammation inhibit less lidocaine Lidocaine base Local lymph nodes much higher overcome P2X7 receptor antagonist paralysis pathologic condition plasma concentration pro-inflammatory progression promote receptor researcher SARS-CoV-2 secondary infections severe inflammation tolerable treated Treatment Treg viral infection
[DOI] 10.1007/s11302-021-09814-6 PMC 바로가기 [Article Type] Commentary

Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19

Chitinase 3-like-1은 COVID-19에서 노화의 영향을 매개하는 치료 표적입니다

Research Article

Published on 2021-11-082022-09-10
Journal: JCI Insight
[Category] MERS, SARS, 유전자 메커니즘, 진단,

Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylation

SARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.

407

Published on 2021-11-032022-08-13
Journal: Proceedings of the National Academy of Sciences of
[Category] Biochemistry, COVID-19, SARS,

[키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism
[DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407